研究员-全讯担保网

魏炜，中国科学院过程工程研究所研究员，博士生导师。2004年本科毕业于北京大学医学部，同年保送进入中国科学院过程工程研究所硕博连读，2011年博士毕业后留所工作至今，先后破格晋升为副研究员和研究员。研究领域主要聚焦于仿生剂型工程，重点基于蛋白、细菌、细胞等天然对象，对载体进行仿生设计，并发展新的制备过程，借助仿生对象体内固有途径实现药物精准递送，应用于抗肿瘤、疫苗、组织修复等领域。

目前，以第一/通讯作者在nature、nat nanotechnol、nat biomed eng、sci transl med、nat commun、sci adv、adv mater、jacs等著名期刊发表sci论文140余篇，包括cns正刊及子刊系列17篇；获中国颗粒学会自然科学一等奖（排名第1）、侯德榜化工科技青年奖、中国科学院院长特别奖、卢嘉锡青年人才奖、中国科学院优秀博士论文奖等；主持了国家基金委杰出青年基金、国家基金委优秀青年基金（结题优秀）、nfsc-广东联合基金、北京市杰出青年基金、重点研发计划课题等；担任中国化工学会生物化工青年学者工作委员会副秘书长、中国颗粒学会青年理事、中国抗癌协会青年理事等。

1. tong ye#, zhouguang jiao#, xin li#, zhanlong he, yanyan li, fengmei yang, xin zhao, youchun wang, weijin huang, meng qin, yingmei feng, yefeng qiu, wenhui yang, lingfei hu, yaling hu, yu zhai, erqiang wang, di yu, shuang wang, hua yue, yishu wang, hengliang wang*, li zhu*, guanghui ma*, wei wei*. inhaled sars-cov-2 vaccine for single-dose dry powder aerosol immunization. nature. 2023. doi: 10.1038/s41586-023-06809-8.

2. xiaohong chen#, shuang wang#, yuxuan chen#, huhu xin, shuaishuai zhang, di wu, yanan xue, menglei zha, hongjun li, kai li, zhen gu, wei wei*, yuan ping*. non-invasive activation of intratumoural gene editing for improved adoptive t-cell therapy in solid tumours. nature nanotechnology. 18, 8, 2023.

3. han bao#, ying tian#, haixin wang, tong ye, shuang wang, jiawei zhao, yefeng qiu, jian li, chao pan, guanghui ma*, wei wei*, yong tao*, exosome-loaded degradable polymeric microcapsules for the treatment of vitreoretinal diseases. nature biomedical engineering. 2023. doi: 10.1038/s41551-023-01112-3.

4. xiaoming hu#, shuang wang#, shaotong fu#, meng qin, chengliang lyu, zhaowen ding, yan wang, yishu wang, dongshu wang, li zhu, tao jiang, jing sun, hui ding, jie wu, lingqian chang, yimin cui, xiaocong pang, youchun wang, weijin huang, peidong yang, limin wang*, guanghui ma*, wei wei*. intranasal mask for protecting the respiratory tract against viral aerosols. nature communications. 2023. doi: 10.1038/s41467-023-44134-w.

5. jiaqi meng#, yanlin lv#, weier bao#, zihuimeng, shuang wang, yuanbin wu, shuping li, zhouguang jiao, zhiyuan tian*, guanghui ma*, wei wei*. generation of whole tumor cell vaccine for on-demand manipulation of immune responses against cancer under near-infrared laser irradiation. nature communications. 2023, 14, 4505.

6. changlong wang#, wei zhang#, yanjie he#, zirui gao, liyuan liu, siyao yu, yuxing hu, shuang wang, chaochao zhao, hui li, jinan shi, wu zhou, feng li, hua yue, yuhua li*, wei wei*, guanghui ma*, ding ma*. ferritin-based targeted delivery of arsenic to diverse leukemia types confers strong anti-leukemia therapeutic effects. nature nanotechnology. 2021, 16, 1413.

7. shuang wang, feng li, tong ye, jianghua wang, chengliang lyu, shuang qing, zhaowen ding, xiaoyong gao, rongrong jia, di yu, jun ren, wei wei*, guanghui ma*. macrophage-tumor chimeric exosomes accumulate in both lymph node and tumor for activation of immune response and tumor microenvironment. science translational medicine. 2021, 13, eabb6981.

8. ying tian#, fan zhang#, yefeng qiu, shuang wang, feng li, jiawei zhao, chao pan, yong tao*, di yu*, wei wei*. reduction of choroidal neovascularization via cleavable vegf antibodies conjugated to exosomes derived from regulatory t cells. nature biomedical engineering. 2021, 5, 968.

9. xiaoling xie#, yuxing hu#, tong ye#, yiran chen, lijuan zhou, feng li, xiaobo xi, shuang wang, yanjie he, xiaoyong gao, wei wei*, guanghui ma*, yuhua li*. therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-pd-1 and a leukaemia-associated antigen. nature biomedical engineering. 2021, 5, 414.

10. yanlin lv#, feng li#, shuang wang, guihong lu, weier bao, yugang wang, zhizuan tian*, wei wei*, guanghui ma*. near-infrared light-triggered platelet arsenal for combined photothermal immunotherapy against cancer. science advances. 2021, 7, eabd7614.